Our research
Feel free to learn more about our published work, we have multiple manuscripts under review so make sure to check back to stay in the loop!
2020: Inhibition of 15-PGDH Protects Mice from Immune-Mediated Bone Marrow Failure. https://pubmed.ncbi.nlm.nih.gov/32422251/
In this manuscript, we showed that inhibiting 15-PGDH protected mice from immune-mediated bone marrow failure. The study demonstrated that combining 15-PGDH inhibition with low-dose immunosuppressive therapy significantly improved hematologic recovery, suggesting a potential therapeutic approach for treating conditions like aplastic anemia
2020: Therapeutic targeting of 15-PGDH in murine pulmonary fibrosis. https://pubmed.ncbi.nlm.nih.gov/32669620/
In this manuscript, we evaluated the therapeutic potential of 15-PGDH inhibition in a mouse model of pulmonary fibrosis. We found that inhibiting 15-PGDH reduced lung fibrosis, inflammation, and improved survival, suggesting this approach could be a promising strategy for treating fibrotic lung diseases.
2021: 15-PGDH inhibition activates the splenic niche to promote hematopoietic regeneration. https://pubmed.ncbi.nlm.nih.gov/33600377/
In this manuscript, we explored how inhibiting 15-PGDH enhances hematopoietic regeneration by activating the splenic microenvironment. Our findings indicate that targeting 15-PGDH supports hematopoietic recovery by promoting interactions between hematopoietic stem cells and their niche, suggesting a potential strategy to improve bone marrow transplantation outcomes.
2021: Polymer Microparticles Prolong Delivery of the 15-PGDH Inhibitor SW033291. https://pubmed.ncbi.nlm.nih.gov/35056981/
In this manuscript, we developed a polymer microparticle delivery system to prolong the release of the 15-PGDH inhibitor SW033291. This approach demonstrated sustained delivery over one week, which could enhance the therapeutic effects of 15-PGDH inhibition in conditions like fibrosis
2022: 15-PGDH regulates hematopoietic and gastrointestinal fitness during aging. https://pubmed.ncbi.nlm.nih.gov/35587945/
In this manuscript, we investigated the role of 15-PGDH in hematopoietic and gastrointestinal aging by studying 15-PGDH knockout (KO) mice. We found that the loss of 15-PGDH improved hematopoietic stem cell function and intestinal health in aged mice, indicating that 15-PGDH plays a crucial role in regulating tissue fitness during aging.
2024: Sex-dependent niche responses modulate steady-state and regenerative hematopoiesis. https://pubmed.ncbi.nlm.nih.gov/38848877/
In this manuscript, we investigated how sex-dependent factors influence hematopoiesis at steady state and during regeneration after hematopoietic stem cell transplantation. We found that male and female hematopoietic stem cells (HSCs) display distinct biological pathways, with females showing a more quiescent and less inflammatory profile, while males exhibited a proliferative advantage, highlighting how sex-specific responses shape normal and regenerative hematopoiesis